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pathway is part of the pathology of COVID-19. Vitamin D   thing,  to  be  able  to  get  significant  amounts  of  these
            is one of the things that’s shown to modulate ACE2 and   different nutrients when everything’s out of season. And
            keep the ACE/ACE2 ratio in the center; because it’s that   vitamin D does not really come from food and  it’s in the
            ratio  of  ACE  and  the  ACE2  keeps  things  stable.    But   sun supply, and the sun supply is extremely low right now.
            because the ACE2 is where the coronaviruses are actually
            docking to, some people are afraid to supplement Vitamin   IMCJ: What about the mineral side, like magnesium, zinc,
            A and D, which support that receptor. But the virus lowers   those types of things?
            the activity of the ACE2 receptor, and that’s part of why
            those  pathologies,  which  already  are  impacted  in  the   Dr Shade: Oh, zinc is a huge one. Magnesium and zinc,
            ACE2,  those  pathologies  are  showing  the  worst   zinc is the biggest one for the immune system; it’s all over
            manifestation. People with those pre-existing conditions   different  immune  reactions,  I  had  read  that  selenium  is
            are  showing  the  worst  pathology  of  the  virus,  and  so   contraindicated for COVID, but I didn’t get the mechanism
            anything  to  help  control  that  is  going  to  control  the   there, so I don’t really know. But zinc, yeah; you go into a
            inflammatory response.                           store,  a  health  food  store  and  the  zinc  section  is  all
               Vitamin D does that, vitamin C is very good for that,   completely sold out. Magnesium is not as powerful for the
            and one of the things that’s emerged has been melatonin;   immune system as zinc, but it is super important. And one
            and melatonin is very big at controlling the very extensive   of the things that people have to do now is not panic so
            inflammatory reactions that happen as you get deeper into   much, not stress so much and just sleep a lot. There you
            the disease, and some of the people that brought this out   can  see  things  like  CBD  and  GABA  and  magnesium,
            referred to melatonin levels in children, which are vastly,   things that calm you down, have this other need, and that’s
            vastly  higher  than  in  older  people.  They’re  even  much   to  get  your  body  out  of  this  sympathetic  fight  or  flight
            higher  than  people  in  their  thirties,  and  the  youngest   situation.
            people are the ones who have almost no symptomology
            from the COVID, from the coronavirus.            IMCJ: Right now we’re in the crisis mode, because we’re
               So,  those  have  been  big  in  control,  and  then  you’ll   trying to avoid a fourth of our population coming down
            find that CBD is really big. CBD is affecting the cannabinoid   with the COVID virus, but reality is probably a fourth of
            receptors  and  the  CB2  receptor  is  very  big  at  dimming   them are and hopefully 90% of them are going to survive
            down  the  excess  inflammation.  Now,  they’re  finding   just fine. But what’s going to happen six months from now,
            things  that  are  immune  suppressants,  like  ibuprofen,   when this thing rears its ugly head again?
            worked  very  negatively  in  these  cases  and  allowed  the
            virus to penetrate much deeper because the inflammation   Dr Shade: Yeah, well... These are things we don’t know,
            is your body’s reaction and attack back against the virus.   theoretically everybody who had it the first time is going
            So, you don’t want to stop inflammation, but you want to   to  be  immune  the  second  time.  They’re  already  talking
            control  it,  so  the  most  extreme  manifestations  of   about taking antibodies from people who survived it, and
            inflammation don’t happen. And so we’ll see, as we move   you know... Plasmapheresis to get IgG from people who
            into  that  side  of  managing  patients,  it’ll  be  around   survived  it,  and  give  it  over  to  people  who  are  sick,  or
            managing  inflammation.  And  just  to  reiterate,  it’ll  be   people who are at risk. So, second time around is one of
            vitamin D, C and Glutathione, I believe will come to be a   the things we don’t know. Because there have been reports
            big  player  there  along  with  Melatonin  and  CBD.  Also   of people getting it a second time, but maybe that was just
            molecular  hydrogen  is  showing  promise.  That’s  been   that it had gone dormant and then it raised itself back up,
            researched  in  China  and  is  showing  a  lot  of  ability  to   or they didn’t know what virus it actually was the first time
            control that runaway inflammation in a similar fashion to   or misdiagnosis the second time. But when it does come
            melatonin.                                       back, which it likely will, I think we’ll know a lot more
                                                             about  which  populations  were  not  infected  or  which
            IMCJ: And so most of these nutrients that you’re talking   populations had totally mild, minor symptoms and what
            about  there,  are  things  that  we  should  get  in  our  food   was their lifestyle like versus the one that had a really hard
            supply, but is there just not any way we can get enough of   time.
            it?                                                  So,  hopefully  good  information  propagates  quickly
                                                             and  when  we  get  back  into  the  winter  again,  when  this
            Dr Shade: Well, it’s hard to get really relevant amounts of   thing will probably raise its head again, hopefully we’ll be
            all  of  these  things  unless  you’re  really  spending  a  lot  of   better prepared for that.
            time  getting  a  lot  of  fresh  fruits  and  vegetables  from
            different areas. All that stuff’s out of season right now in   IMCJ: You mentioned a little bit about the CBD side, this
            North America, so you’re going to have to move stuff in   is probably one of the first conditions that CBD has been
            from the rest of the world and concentrate it down. So, this   around legally for, that we could use to fight it.
            is an example of where supplementation is really a great


            Shade—Immune Support                                            Integrative Medicine • Vol. 19, No. 2 • April 2020  39
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