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in the majority of large coenzyme Q  clinical trials around   6.  Littarru GP and Tiano L. Coenzyme Q10: Recent Developments. Molecular
                                                                 Biotechnology. 2007;37:31-37.
                                        10
            the world over the past thirty years.             7.  Kagan VE, et al. Role of Coenzyme Q and Superoxide in Vitamin E recycling.
               The  slide/image  above  shows  how  Pharma  Nord’s   Subcell Biochem. 1998;30:491-507.
            patented  process  keeps  their  coenzyme  Q   in  solution,   8.  Albano  CB,  et  al  Distribution  of  Coenzyem  Q  Homologues  in  Brain.
                                                                 Neurochem Res. May 2002;27(5):359-68.
                                               10
            which  results  in  a  product  that  is  largely  crystal  free.   9.  Gao  S  and  Liu  J.  Association  between  circulating  oxidized  low-density
            Coenzyme Q  is an incredibly important nutrient, but in   lipoprotein  and  atherosclerotic  cardiovascular  disease.  Chronic Dis Transl
                                                                 Med. 2017 Jun 25;3(2):89-94.
                      10
            order  to  be  effective,  it  must  be  well  absorbed  and   10.  Mortensen  SA.  Dose-related  decrease  of  serum  coenzyme  Q10  during
            bioavailable.  That’s  why  I  use  and  recommend  Pharma   treatment with HMG-CoA reductase inhibitors. Mol Aspects Med. 1997;18
                                                                 Suppl:S137-44.
            Nord’s Bio-Quinone Active CoQ  GOLD.              11.  Sharma A, et al. Coenzyme Q10 and Heart Failure: A State-of-the-Art Review.
                                     10
                                                                 Circ Heart Fail. 9(4):e002639.
                                                              12.  Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality
            To Order: Practitioners, if you would like to get product   in chronic heart failure: results from Q-SYMBIO: a randomized double-blind
                                                                 trial. JACC. Heart Failure. 2014, 2(6): 641-649.
            information  or  order  Pharma  Nord’s  Bio-Quinone  for   13.  Mortensen SA, et al. Effect of Coenzyme Q10 in Europeans with chronic heart
            yourself  or  for  your  patients,  send  a  request  to:     failure:  A  sub-group  analysis  of  the  Q-Symbio  randomized  double-blind
            practitioner@pharmanord.com                          study. Cardiology Journal. 2019, 26(2): 147-156.
                                                              14.  Slehagen U, et al. Cardiovascular mortality and N-terminal-proBNP reduced
                                                                 after  combined  selenium  and  coenzyme  Q10  supplementation:  a  5-year
            References                                           prospective randomized double-blind, placebo-controlled trial among elderly
             1.  Folkers K, Littarru GP, Ho L, Runge TM, Havanonda S, & Cooley D. (1970).   Swedish citizens. International Journal of Cardiology. 2013, 167(5): 1860-1866.
               Evidence  for  a  deficiency  of  coenzyme  Q10  in  human  heart  disease.   15.  Langsjoen P, et al. Treatment of Essential Hypertension With Coenzyme Q10.
               International Journal of Vitamin Research 40(3):380-90.  Mol Aspects Med. 1994;15 Suppl: S265-72.
             2.  NobelPrize.org. 2020. The Nobel Prize In Chemistry 1978. [online] Available   16.  Folkers K, et al. Activities of vitamin Q10 in animal models and a serious
               at: https://www.nobelprize.org/prizes/chemistry/1978/summary/ Accessed 23   deficiency in patients with cancer. Biochem Biophys Res Commun 234:296-
               March 2020].                                      299, 1997.
             3.  Pelton  R.  The Drug-Induced Nutrient Depletion Handbook  (2nd Edition).   17.  Seyfried T. Cancer as a Metabolic Disease: On the Origin, Management and
               Hudson, OH, Lexi-Comp, 2001.                      Prevention of Cancer. Hoboken, NJ. John Wyley & Sons, Inc. 2012.
             4.  De  Barcelos  IP  and  Haas  RH.  CoQ10  and  Aging.  Biology (Basel).  2019   18.  Ernster L and Dallner G. Biochemical, physiological and medical aspects of
               Jun;8(2):28.                                      ubiquinone function. Biochim Biophys Acta. May 24, 1995;1271(1):195-204.
             5.  Ernster L and Forsmakr-Andree P. Ubiquinol: An Endogenous Antioxidant in   19.  Lockwood K, et al. Partial and complete regression of breast cancer in patients
               Aerobic Organisms. Clin Investig. 1973;71(8 Suppl):S60-65.  in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun. 1994
                                                                 Mar 30;199(3):1504-8.
       20   Integrative Medicine • Vol. 19, No. 2 • April 2020                               Pelton—Coenzyme Q 10
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