Page 20 - IMCJ April 2020

Langsjoen Hypertension Study decreased immunity and aging bodily functions. Fifty
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Cardiologist Peter Langsjoen selected 109 patients mice regularly received CoQ ; the other 50 old mice
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with essential hypertension. Patients added high-dose served as controls. All mice were maintained on optimally
CoQ (average dose 225 mg/day) to their existing nutritious diets.
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antihypertensive drugs.
RESULT: New York Heart Association (NYHA) • At 36 weeks into the study, 100% of the control
functional class improved from a mean of 2.40 to 1.36, and mice were dead while 40% of the CoQ -treated
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51% of patients came completely off from 1 to 3 blood mice were still alive, active and not showing the
pressure meds within average of 4.4 months after starting normal signs of physical deterioration commonly
high-dose CoQ . 15 associated with advanced age.
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• At week 56, 10% of the CoQ -treated mice were
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CoQ & Cancer still alive and thriving. This is 2X longer than these
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Studies reveal that cancer patients have low levels of mice would normally be expected to survive beyond
coenzyme Q . Thomas Seyfried, MD has written an the beginning of the experiment.
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important book titled Cancer as a Metabolic Disease: On • At the 80th week 4 mice were still alive; at the 82nd
the Origin, Management and Prevention of Cancer. week, the last mouse died. In human terms, this is a
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Seyfried explains that cancer is a metabolic disease that life span of roughly 130 years of age! (the last
initiates with damage to mitochondrial DNA, which control mouse died at week 36).
hinders the ability of cells to produce adequate energy.
This causes the metabolic shift from oxygen to glucose for I spoke with Dr. Bliznakov personally, and he
energy production, which is the hallmark of cancer cell explained the following remarkable visual differences
metabolism. Coenzyme Q in its reduced form—ubiquinol between the two groups of mice at 30 weeks, when some
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plays a critically important role in mitochondria by of the control mice were still alive. The fur on the controls
protecting mitochondrial membranes and mitochondrial was dull, coarse, matted and on some mice, clumps of hair
DNA (mtDNA) from free radical damage. had fallen out, leaving bald patchy spots. All the remaining
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Breast Cancer. In a small study, 32 advanced breast control mice were very listless and spent most of their time
cancer patients with lymph metastasis were treated with lying around and not socializing. On the other hand, the
390 mg of CoQ daily. Either partial or complete tumor fur in the coats of the CoQ -treated mice remained
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regression was documented in 6 of the 32 women. smooth and soft, and they maintained a much greater level
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Prostate Cancer. In men with prostate cancer, of activity and socialization.
treatment with high-dose CoQ resulted in substantial
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reductions in PSA and tumor size. An important finding Ubiquinone vs Ubiquinol
was that the men did not begin to show any signs of CoQ is poorly absorbed because of its lipophilic
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response until about 90 days into the trial. 20 nature and its large molecular weight. In 2006, Kaneka
Reducing Chemotherapy Side Effects. clinical trials Corporation in Japan began marketing the ubiquinol
have also reported that coenzyme Q substantially protects (reduced) form of CoQ with claims that it was better
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against and/or reduces side effects in patients undergoing absorbed than ubiquinone and hence, more effective. This
various forms of chemotherapy. 21 has been a very successful marketing strategy for Kaneka,
Neurological Conditions. Reduced levels of but actually, the claims are not scientifically accurate.
coenzyme Q are associated with several neurological Ubiquinol CoQ products are substantially more
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diseases and its ability to reduce oxidative stress suggests expensive than ubiquinone CoQ products. However,
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that CoQ may be able to slow the progression and in when ubiquinol is ingested, it is oxidized by gastric acid to
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some cases, possibly provide some therapeutic benefit. ubiquinone before it is absorbed. Hence, people pay
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Conditions in which CoQ may play a role include more for ubiquinol, but really do not get added benefit(s).
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Parkinson’s disease , Huntington’s disease and Research has shown that it is not necessary to take
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Alzheimer’s disease. 24 ubiquinol in order to significantly increase ubiquinol
Life Extension. Coenzyme Q ’s ability to protect levels in plasma and in plasma lipoproteins. Taking a
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mitochondria against excessive free radical damage makes ubiquinone supplement will do the same. 27
it a candidate for consideration as a life extension nutrient.
Although studies in animal models have had mixed Dosing Advice
results, a study conducted by Emile Bliznakov, MD has The following advice pertains to all CoQ products,
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fascinating implications. regardless of the type of CoQ being taken. Coenzyme Q
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Dr. Bliznakov started his experiment with 100 “old” is a fat-soluble nutrient and humans do not absorb fat-
female white mice 16 to 18 months of age, which is soluble nutrients very efficiently. CoQ supplements
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equivalent to humans in their 60s to 70s. Being elderly, should be taken at a meal that contains some fat. This
these mice were already beginning to show some signs of enhances the absorption of the CoQ .
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18 Integrative Medicine • Vol. 19, No. 2 • April 2020 Pelton—Coenzyme Q 10