Page 21 - IMCJ April 2020

The following data was gathered from multiple human effectiveness) of coenzyme Q . One is the composition of
10
clinical trials. On average, participants’ pre-test CoQ the oil matrix in which the CoQ is dissolved and the
10
10
blood levels were 1.09 ug/ml. After ingestion of a single second factor is the heating and cooling process used prior
100 mg dose of CoQ , blood levels increased to 2.33 ug/ml. to filling the coenzyme Q /oil mixture into the soft-gel
10
10
However, when people ingested 200 mg of CoQ in a capsules. These are the factors that differentiate between a
10
single dose, the blood level only increased to 2.35 ug/ml— crystal free CoQ product vs a product with CoQ
10
10
almost no different than the blood level following a crystals.
100 mg dose. However, when individuals took 100 mg of
CoQ in divided doses, twice daily, blood levels rose to Crystal Free CoQ 10
10
3.47 ug/ml. Numerous companies that produce coenzyme Q
10
Because coenzyme Q is a large molecular weight, products are engaged in research to develop their own
10
fat-soluble compound, its absorption is slow and limited. patented delivery system that keeps their CoQ in
10
This explains why better blood levels are achieved with solution, both in the capsule and after it has been ingested.
divided doses rather than taking a large single dose of These are called Crystal Free coenzyme Q products.
10
coenzyme Q . 28 Pharma Nord is a Denmark-based company that that
10
has been committed to producing quality coenzyme Q
10
The Crystallization Problem products for over 30 years. During the 1990s they funded
CoQ ’s melting point is 10°C higher than human numerous absorption and bioavailability studies on their
10
body temperature, which equates to about 118° F. Bio-Quinone Active CoQ GOLD product. These
TM
10
Consequently, at temperatures below 118° F, single studies confirmed that their patented oil mixture provided
molecules of CoQ dissolved in water or oil begin to a crystal free product that is well absorbed. 30,31,32
10
clump into crystals. We cannot absorb CoQ crystals; we
10
can only absorb single molecules. Upon microscopic Industry Acceptance
examination, many CoQ softgel capsules contain crystals, Pharma Nord’s willingness to fund studies that
10
which partially explains why many CoQ products have document the superior absorbability of their Bio-Quinone
10
low absorbability. Even CoQ products that are dissolved CoQ resulted in their products being selected to be used
10
10
in oil recrystallize in the body, which prevents absorption. in a majority of the large clinical trials conducted around
the world. To date, 78 human studies have been conducted
Absorption Studies using Bio-Quinone Active CoQ GOLD, and 26 of these
10
Until recently, there was a lack of standardization in studies are randomized, double-blind, placebo-controlled
most CoQ absorption studies, which made it difficult to studies with 30 or more participants.
10
make product comparisons. However, a recently published,
head-to-head study that compared the absorption of CoQ & Immunity
10
variously formulated ubiquinone products with a The global COVID-19/coronavirus pandemic has
well-formulated ubiquinol product, revealed conclusively made people much more conscious about taking steps to
that a well-formulated ubiquinone product is about 200% boost their immune system. Coenzyme Q supports and/
10
better absorbed than ubiquinol products. However, this or enhances immune function in the following ways:
29
is not the end of the story. stimulates production of red blood cells and hemoglobin ,
33
improves ratio between T4/T8 lymphocytes , increases
34
The Oil Matrix production of natural killer cells and stimulates the
35
William Judy, PhD, has been a highly respected production of antibodies. Thus, coenzyme Q should be
36
10
coenzyme Q scientist for over 40 years. In the past considered along nutrients like vitamin C and vitamin D,
10
several years, he has focused on CoQ absorption issues as important natural therapies to enhance immune
10
and conducting CoQ absorption studies. Dr. Judy’s function.
10
absorption studies have led him to realize that the form of
coenzyme Q in a product (ubiquinone or ubiquinol) is Bio-Quinone’s Superior Absorbability
10
less important than the oil matrix that the CoQ is One of the world’s leading coenzyme Q scientists,
10
10
dissolved in. Most coenzyme Q products are not simply Dr. Guillermo Lopez-Lluch of Spain, conducted a
10
CoQ , they contain other ingredients such as various oils bioavailability study with seven of the leading coenzyme Q
10
10
or a substance like piperine, which is a compound derived formulations on the market. In this double-blind, crossover
from black pepper. These substances may enhance the study, individuals were given a single 100 mg dose of
absorption of coenzyme Q . CoQ and plasma CoQ levels were measured 48 hours
10 10 10
after ingestion. Pharma Nord’s Bio-Quinone was found to
Formulation is More Important Than Form be from 3 to 10 times better absorbed than the other 6
Dr. Judy’s research has revealed that the following two brands tested. This explains why Pharma Nord’s Bio-
37
important factors determine the absorption (and Quinone has been the CoQ product selected to be used
10
Pelton—Coenzyme Q 10 Integrative Medicine • Vol. 19, No. 2 • April 2020 19